Jornada 1 08/08/2021
| Sporting CP | 3 – 0 | FC Vizela |
| FC Arouca | 0 – 2 | Estoril Praia |
| Moreirense FC | 1 – 2 | SL Benfica |
| Marítimo M. | 0 – 2 | SC Braga |
| Vitória SC | 0 – 1 | Portimonense |
| CD Tondela | 3 – 0 | Santa Clara |
| FC Porto | 2 – 0 | Belenenses SAD |
| FC P.Ferreira | 2 – 0 | FC Famalicão |
| Gil Vicente FC | 3 – 0 | Boavista FC |
Jornada 2 14/08/2021
| Estoril Praia | 0 – 0 | Vitória SC |
| FC Vizela | 2 – 1 | CD Tondela |
| SL Benfica | 2 – 0 | FC Arouca |
| SC Braga | 1 – 2 | Sporting CP |
| Portimonense | 0 – 1 | Gil Vicente FC |
| FC Famalicão | 1 – 2 | FC Porto |
| Santa Clara | 2 – 2 | Moreirense FC |
| Boavista FC | 3 – 0 | FC P.Ferreira |
| Belenenses SAD | 1 – 2 | Marítimo M. |
Jornada 3 22/08/2021
| FC Arouca | 2 – 1 | FC Famalicão |
| Moreirense FC | 2 – 3 | SC Braga |
| Gil Vicente FC | 0 – 2 | SL Benfica |
| Sporting CP | 2 – 0 | Belenenses SAD |
| CD Tondela | 0 – 3 | Portimonense |
| Marítimo M. | 1 – 1 | FC Porto |
| Vitória SC | 4 – 0 | FC Vizela |
| FC P.Ferreira | 1 – 3 | Estoril Praia |
| Boavista FC | 2 – 0 | Santa Clara |
Jornada 4 29/08/2021
| Belenenses SAD | 1 – 1 | Moreirense FC |
| Estoril Praia | 2 – 1 | Marítimo M. |
| FC Vizela | 1 – 1 | Boavista FC |
| FC Porto | 3 – 0 | FC Arouca |
| FC Famalicão | 1 – 1 | Sporting CP |
| SL Benfica | 2 – 1 | CD Tondela |
| SC Braga | 0 – 0 | Vitória SC |
| Santa Clara | 1 – 0 | Gil Vicente FC |
| Portimonense | 0 – 1 | FC P.Ferreira |
Jornada 5 12/09/2021
| FC P.Ferreira | 0 – 0 | SC Braga |
| Santa Clara | 0 – 5 | SL Benfica |
| Sporting CP | 1 – 1 | FC Porto |
| Moreirense FC | 2 – 2 | FC Famalicão |
| Gil Vicente FC | 2 – 2 | FC Vizela |
| Boavista FC | 1 – 1 | Portimonense |
| Vitória SC | 0 – 0 | Belenenses SAD |
| Marítimo M. | 2 – 2 | FC Arouca |
| CD Tondela | 1 – 2 | Estoril Praia |
Jornada 6 19/09/2021
| Portimonense | 2 – 1 | Santa Clara |
| FC Famalicão | 0 – 0 | Marítimo M. |
| Belenenses SAD | 1 – 1 | Gil Vicente FC |
| FC Arouca | 2 – 2 | Vitória SC |
| FC Vizela | 1 – 1 | FC P.Ferreira |
| FC Porto | 5 – 0 | Moreirense FC |
| Estoril Praia | 0 – 1 | Sporting CP |
| SL Benfica | 3 – 1 | Boavista FC |
| SC Braga | 3 – 1 | CD Tondela |
Jornada 7 26/09/2021
| Sporting CP | 1 – 0 | Marítimo M. |
| Gil Vicente FC | 1 – 2 | FC Porto |
| Moreirense FC | 2 – 1 | FC Arouca |
| Vitória SC | 1 – 3 | SL Benfica |
| CD Tondela | 3 – 2 | FC Famalicão |
| Santa Clara | 1 – 1 | SC Braga |
| Portimonense | 0 – 0 | FC Vizela |
| FC P.Ferreira | 2 – 2 | Belenenses SAD |
| Boavista FC | 1 – 1 | Estoril Praia |
Jornada 8 03/10/2021
| Marítimo M. | 0 – 0 | Moreirense FC |
| FC Famalicão | 1 – 2 | Vitória SC |
| FC Vizela | 1 – 1 | Santa Clara |
| FC Porto | 2 – 1 | FC P.Ferreira |
| FC Arouca | 1 – 2 | Sporting CP |
| Belenenses SAD | 0 – 2 | CD Tondela |
| SL Benfica | 0 – 1 | Portimonense |
| Estoril Praia | 2 – 2 | Gil Vicente FC |
| SC Braga | 2 – 2 | Boavista FC |
Jornada 9 24/10/2021
| Vitória SC | 2 – 1 | Marítimo M. |
| Santa Clara | 0 – 2 | FC Famalicão |
| CD Tondela | 1 – 3 | FC Porto |
| Sporting CP | 1 – 0 | Moreirense FC |
| FC P.Ferreira | 0 – 0 | FC Arouca |
| FC Vizela | 0 – 1 | SL Benfica |
| Portimonense | 0 – 2 | Estoril Praia |
| Gil Vicente FC | 0 – 1 | SC Braga |
| Boavista FC | 0 – 0 | Belenenses SAD |
Jornada 10 31/10/2021
| FC Arouca | 2 – 0 | CD Tondela |
| FC Porto | 4 – 1 | Boavista FC |
| Estoril Praia | 1 – 1 | SL Benfica |
| Sporting CP | 1 – 0 | Vitória SC |
| Marítimo M. | 1 – 2 | Gil Vicente FC |
| Belenenses SAD | 2 – 1 | Santa Clara |
| FC Famalicão | 1 – 1 | FC Vizela |
| SC Braga | 3 – 0 | Portimonense |
| Moreirense FC | 1 – 1 | FC P.Ferreira |
Jornada 11 07/11/2021
| Gil Vicente FC | 1 – 1 | FC Arouca |
| Boavista FC | 2 – 5 | FC Famalicão |
| FC Vizela | 1 – 1 | Estoril Praia |
| Portimonense | 2 – 0 | Belenenses SAD |
| Vitória SC | 2 – 1 | Moreirense FC |
| CD Tondela | 4 – 2 | Marítimo M. |
| Santa Clara | 0 – 3 | FC Porto |
| FC P.Ferreira | 0 – 2 | Sporting CP |
| SL Benfica | 6 – 1 | SC Braga |
Jornada 12 28/11/2021
| Moreirense FC | 2 – 2 | Gil Vicente FC |
| FC Famalicão | 0 – 3 | Portimonense |
| FC Arouca | 2 – 1 | Boavista FC |
| Belenenses SAD | 0 – 7 | SL Benfica |
| Marítimo M. | 2 – 0 | FC P.Ferreira |
| Sporting CP | 2 – 0 | CD Tondela |
| FC Porto | 2 – 1 | Vitória SC |
| Estoril Praia | 2 – 2 | Santa Clara |
| SC Braga | 4 – 1 | FC Vizela |
Jornada 13 05/12/2021
| Portimonense | 0 – 3 | FC Porto |
| SL Benfica | 1 – 3 | Sporting CP |
| Boavista FC | 1 – 1 | Marítimo M. |
| FC P.Ferreira | 1 – 2 | Vitória SC |
| Santa Clara | 2 – 1 | FC Arouca |
| Gil Vicente FC | 4 – 0 | FC Famalicão |
| SC Braga | 2 – 0 | Estoril Praia |
| FC Vizela | 2-0 | Belenenses SAD |
| CD Tondela | 2-1 | Moreirense FC |
Jornada 14 12/12/2021
| FC P.Ferreira | 0 – 1 | Gil Vicente FC |
| Marítimo M. | 4 – 1 | Santa Clara |
| Vitória SC | 5 – 2 | CD Tondela |
| Sporting CP | 2 – 0 | Boavista FC |
| Moreirense FC | 0 – 1 | Portimonense |
| Belenenses SAD | 0 – 1 | Estoril Praia |
| FC Famalicão | 1 – 4 | SL Benfica |
| FC Porto | 1 – 0 | SC Braga |
| FC Arouca | 1 – 4 | FC Vizela |
Jornada 15 19/12/2021
| Santa Clara | 1 – 0 | Vitória SC |
| Estoril Praia | 2 – 2 | FC Famalicão |
| Portimonense | 1 – 1 | FC Arouca |
| CD Tondela | 0 – 1 | FC P.Ferreira |
| Gil Vicente FC | 0 – 3 | Sporting CP |
| Boavista FC | 1 – 0 | Moreirense FC |
| SL Benfica | 7 – 1 | Marítimo M. |
| FC Vizela | 0 – 4 | FC Porto |
| SC Braga | 1-0 | Belenenses SAD |
Jornada 16 29/12/2021
| CD Tondela | 0-3 | Gil Vicente FC |
| Marítimo M. | 2-0 | FC Vizela |
| Moreirense FC | 1-0 | Estoril Praia |
| FC Famalicão | 1 – 0 | Belenenses SAD |
| Vitória SC | 1-1 | Boavista FC |
| Sporting CP | 3-2 | Portimonense |
| FC P.Ferreira | 2-1 | Santa Clara |
| FC Arouca | 0-6 | SC Braga |
| FC Porto | 3-1 | SL Benfica |
Jornada 17 08/01/2022
| SL Benfica | 2-0 | FC P.Ferreira |
| SC Braga | 2-2 | FC Famalicão |
| Santa Clara | 3-2 | Sporting CP |
| Belenenses SAD | 2-1 | FC Arouca |
| Gil Vicente FC | vs | Vitória SC |
| Boavista FC | 1-1 | CD Tondela |
| Portimonense | 1-2 | Marítimo M. |
| Estoril Praia | 2-3 | FC Porto |
| FC Vizela | 0-1 | Moreirense FC |
Jornada 18 16/01/2022
| FC Vizela | 0 – 2 | Sporting CP |
| Belenenses SAD | 1 – 4 | FC Porto |
| FC Famalicão | 0 – 2 | FC P.Ferreira |
| Portimonense | 1 – 1 | Vitória SC |
| SL Benfica | 1 – 1 | Moreirense FC |
| Boavista FC | 1 – 1 | Gil Vicente FC |
| Santa Clara | 2 – 2 | CD Tondela |
| SC Braga | 0 – 1 | Marítimo M. |
| Estoril Praia | 1 – 2 | FC Arouca |
Jornada 19 23/01/2022
| FC Arouca | 0 – 2 | SL Benfica |
| Sporting CP | 1 – 2 | SC Braga |
| Moreirense FC | 0 – 2 | Santa Clara |
| FC Porto | 3 – 1 | FC Famalicão |
| Marítimo M. | 1 – 1 | Belenenses SAD |
| FC P.Ferreira | 1 – 1 | Boavista FC |
| Gil Vicente FC | 1 – 0 | Portimonense |
| Vitória SC | 3 – 1 | Estoril Praia |
| CD Tondela | 2 – 3 | FC Vizela |
Jornada 20 30/01/2022
| Belenenses SAD | 1 – 4 | Sporting CP |
| Estoril Praia | 0 – 0 | FC P.Ferreira |
| FC Vizela | 3 – 2 | Vitória SC |
| SC Braga | 2 – 0 | Moreirense FC |
| SL Benfica | 1 – 2 | Gil Vicente FC |
| Portimonense | 1 – 2 | CD Tondela |
| Santa Clara | 2 – 1 | Boavista FC |
| FC Porto | 2 – 1 | Marítimo M. |
| FC Famalicão | 0 – 0 | FC Arouca |
Jornada 21 06/02/2022
| FC Arouca | 0 – 2 | FC Porto |
| CD Tondela | 1 – 3 | SL Benfica |
| Vitória SC | 2 – 1 | SC Braga |
| Gil Vicente FC | 2 – 2 | Santa Clara |
| Sporting CP | 2 – 0 | FC Famalicão |
| Moreirense FC | vs | Belenenses SAD |
| FC P.Ferreira | 1 – 1 | Portimonense |
| Marítimo M. | 0 – 0 | Estoril Praia |
| Boavista FC | 2 – 2 | FC Vizela |
Jornada 22 13/02/2022
| FC Porto | 2 – 2 | Sporting CP |
| SC Braga | 2 – 1 | FC P.Ferreira |
| SL Benfica | 2 – 1 | Santa Clara |
| Belenenses SAD | 1 – 0 | Vitória SC |
| FC Famalicão | 5 – 0 | Moreirense FC |
| FC Vizela | 0 – 1 | Gil Vicente FC |
| Estoril Praia | 1 – 0 | CD Tondela |
| Portimonense | 1 – 1 | Boavista FC |
| FC Arouca | 0 – 3 | Marítimo M. |
Jornada 23 20/02/2022
| Moreirense FC | 0 – 1 | FC Porto |
| Boavista FC | 2 – 2 | SL Benfica |
| CD Tondela | 0 – 1 | SC Braga |
| Marítimo M. | 0 – 1 | FC Famalicão |
| Gil Vicente FC | 2 – 0 | Belenenses SAD |
| Santa Clara | 1 – 1 | Portimonense |
| Sporting CP | 3 – 0 | Estoril Praia |
| FC P.Ferreira | 2 – 1 | FC Vizela |
| Vitória SC | 1 – 3 | FC Arouca |
Jornada 24 27/02/2022
| Marítimo M. | 1 – 1 | Sporting CP |
| Belenenses SAD | 0 – 2 | FC P.Ferreira |
| SC Braga | 0 – 0 | Santa Clara |
| SL Benfica | 3 – 0 | Vitória SC |
| FC Arouca | 1 – 1 | Moreirense FC |
| FC Porto | 1 – 1 | Gil Vicente FC |
| FC Famalicão | 2 – 1 | CD Tondela |
| Estoril Praia | 2 – 3 | Boavista FC |
| FC Vizela | 1 – 1 | Portimonense |
Jornada 25 06/03/2022
| FC P.Ferreira | 2 – 4 | FC Porto |
| Portimonense | 1 – 2 | SL Benfica |
| Boavista FC | 1 – 1 | SC Braga |
| Vitória SC | 2 – 1 | FC Famalicão |
| CD Tondela | 1 – 1 | Belenenses SAD |
| Moreirense FC | 0 – 1 | Marítimo M. |
| Gil Vicente FC | 0 – 0 | Estoril Praia |
| Santa Clara | 3 – 1 | FC Vizela |
| Sporting CP | 2 – 0 | FC Arouca |
Jornada 26 13/03/2022
| Moreirense FC | 0 – 2 | Sporting CP |
| FC Arouca | 0 – 1 | FC P.Ferreira |
| FC Famalicão | 0 – 0 | Santa Clara |
| Marítimo M. | 0 – 1 | Vitória SC |
| SC Braga | 0 – 1 | Gil Vicente FC |
| FC Porto | 4 – 0 | CD Tondela |
| Belenenses SAD | 0 – 0 | Boavista FC |
| Estoril Praia | 2 – 0 | Portimonense |
| SL Benfica | 1 – 1 | FC Vizela |
Jornada 27 20/03/2022
| Vitória SC | 1 – 3 | Sporting CP |
| Boavista FC | 0 – 1 | FC Porto |
| Portimonense | 1 – 2 | SC Braga |
| FC P.Ferreira | 2 – 1 | Moreirense FC |
| FC Vizela | 1 – 1 | FC Famalicão |
| Santa Clara | 0 – 0 | Belenenses SAD |
| Gil Vicente FC | 1 – 1 | Marítimo M. |
| SL Benfica | 2 – 1 | Estoril Praia |
| CD Tondela | 2 – 2 | FC Arouca |
Jornada 28 03/04/2022
| SC Braga | 3 – 2 | SL Benfica |
| Sporting CP | 2 – 1 | FC P.Ferreira |
| FC Porto | 3 – 0 | Santa Clara |
| Moreirense FC | 0 – 1 | Vitória SC |
| FC Arouca | 2 – 1 | Gil Vicente FC |
| Marítimo M. | 1 – 3 | CD Tondela |
| FC Famalicão | 1 – 2 | Boavista FC |
| Belenenses SAD | 2 – 0 | Portimonense |
| Estoril Praia | 1 – 2 | FC Vizela |
Jornada 29 10/04/2022
| CD Tondela | 1 – 3 | Sporting CP |
| Vitória SC | 0 – 1 | FC Porto |
| FC Vizela | 0 – 1 | SC Braga |
| Gil Vicente FC | 1 – 2 | Moreirense FC |
| Portimonense | 1 – 0 | FC Famalicão |
| SL Benfica | 3 – 1 | Belenenses SAD |
| FC P.Ferreira | 2 – 0 | Marítimo M. |
| Santa Clara | 2 – 0 | Estoril Praia |
| Boavista FC | 1 – 0 | FC Arouca |
Jornada 30 16/04/2022
| Sporting CP | 0 – 2 | SL Benfica |
| Estoril Praia | 0 – 0 | SC Braga |
| Vitória SC | 1 – 0 | FC P.Ferreira |
| FC Arouca | 1 – 1 | Santa Clara |
| FC Famalicão | 2 – 2 | Gil Vicente FC |
| Moreirense FC | 4 – 0 | CD Tondela |
| Marítimo M. | 4 – 0 | Boavista FC |
| FC Porto | 7 – 0 | Portimonense |
| Belenenses SAD | 1 – 0 | FC Vizela |
Jornada 31 24/04/2022
| Boavista FC | 0 – 3 | Sporting CP |
| SC Braga | 1 – 0 | FC Porto |
| Gil Vicente FC | 1 – 1 | FC P.Ferreira |
| CD Tondela | 1 – 1 | Vitória SC |
| Portimonense | 1 – 0 | Moreirense FC |
| SL Benfica | 0 – 0 | FC Famalicão |
| Estoril Praia | 2 – 2 | Belenenses SAD |
| Santa Clara | 2 – 2 | Marítimo M. |
| FC Vizela | 2 – 1 | FC Arouca |
Jornada 32 30/04/2022
| Marítimo M. | 0 – 1 | SL Benfica |
| Belenenses SAD | 0 – 1 | SC Braga |
| Vitória SC | 1 – 1 | Santa Clara |
| Sporting CP | 4 – 1 | Gil Vicente FC |
| FC P.Ferreira | 1 – 1 | CD Tondela |
| Moreirense FC | 1 – 2 | Boavista FC |
| FC Arouca | 1 – 0 | Portimonense |
| FC Famalicão | 3 – 1 | Estoril Praia |
| FC Porto | 4 – 2 | FC Vizela |
Jornada 33 08/05/2022
| Portimonense | 2 – 3 | Sporting CP |
| SL Benfica | 0 – 1 | FC Porto |
| Santa Clara | 2 – 0 | FC P.Ferreira |
| Boavista FC | 1 – 1 | Vitória SC |
| Estoril Praia | 1 – 0 | Moreirense FC |
| Belenenses SAD | 2 – 3 | FC Famalicão |
| Gil Vicente FC | 3 – 0 | CD Tondela |
| FC Vizela | 1 – 1 | Marítimo M. |
| SC Braga | 1 – 0 | FC Arouca |
Jornada 34 15/05/2022
| FC P.Ferreira | 0 – 2 | SL Benfica |
| FC Famalicão | 3 – 2 | SC Braga |
| Sporting CP | 4 – 0 | Santa Clara |
| FC Arouca | 0 – 0 | Belenenses SAD |
| Vitória SC | 5 – 0 | Gil Vicente FC |
| CD Tondela | 2 – 2 | Boavista FC |
| Marítimo M. | 0 – 1 | Portimonense |
| FC Porto | 2 – 0 | Estoril Praia |
| Moreirense FC | 4 – 1 | FC Vizela |
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